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1992-11-14
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127 lines
UI - 92411223
EM - 9212
AU - Sorace JM ; Carnahan GE ; Moore GW ; Berman JJ
TI - Automated review of blood donor screening test patterns at a
regional blood center.
SO - Am J Clin Pathol 1992 Sep;98(3):334-44
UI - 92409124
EM - 9212
AU - Krueger M
TI - Virtual reality: a technology in nursing education's future
[interview]
SO - Nurs Educ Microworld 1991 Feb-Mar;5(3):17, 19
1
AU - Frackowiak J
AU - Wisniewski HM
AU - Wegiel J
AU - Merz GS
AU - Iqbal K
AU - Wang KC
TI - Ultrastructure of the microglia that phagocytose amyloid and
the microglia that produce Beta-amyloid fibrils
AB - The function of microglia associated with beta-amyloid deposits
still remains a controversial issue. On the basis of recent
ultrastructural data, microglia were postulated to be cells
that form amyloid fibrils not phagocytes that remove amyloid
deposits. In this electron microscopic study, we examined the
ability of microglia to ingest and digest exogenous amyloid
fibrils in vitro.We demonstrate that amyloid fibrils are ingested
by cultured microglial cells and collected and stored in phagosomes.
The ingested nondegraded amyloid remains within phagosomes
for up to 20 days, suggesting a very limited effectiveness
of microglia in degrading beta- amyloid fibrils. On the other
hand, we showed that in microglial cells of classical plaques
in brain cortex of patients with Alzheimer's disease, amyloid
fibrils appear first in altered endoplasmic reticulum and deep
infoldings of cell membranes. These differences in intracellular
distribution of amyloid fibrils in microglial cells support
our observations that microglial cells associated with amyloid
plaques are engaged in production of amyloid, but not in phagocytosis.
AUTHOR
Reference Number : 18; Reference Type :Article
Dr. H.M. Wisniewski
Pathological Neurobiology
NY State Inst for Basic Res
1050 Forest Hill Rd
Staten Island, NY 10314
USA
MH - Alzheimer's disease
MH - Tissue culture
MH - Microglia
MH - Amyloid
MH - Ultrastructure
SO - Acta Neuropathologica 1992 Aug;84(3):225-233
1
UI - JL140
AU - Frackowiak J
AU - Wisniewski HM
AU - Wegiel J
AU - Merz GS
AU - Iqbal K
AU - Wang KC
TI - Ultrastructure of the Microglia That Phagocytose Amyloid
and the Microglia That Produce beta-Amyloid Fibrils.
LA - English
RF - Article
AD - HM Wisniewski, New York State Inst Basic,
Res Dev Disabilities, Dept Pathol Neurobiol,
1050 Forest Hill Rd, Staten Isl, NY 10314.
AB - The function of microglia associated with beta-amyloid
deposits still remains a controversial issue. On the
basis of recent ultrastructural data, microglia were
postulated to be cells that form amyloid fibrils, not
phagocytes that remove amyloid deposits. In this
electron microscopic study, we examined the ability of
microglia to ingest and digest exogenous amyloid fibrils
in vitro.We demonstrate that amyloid fibrils are
ingested by cultured microglial cells and collected and
stored in phagosomes. The ingested, nondegraded amyloid
remains within phagosomes for up to 20 days, suggesting
a very limited effectiveness of microglia in degrading
beta-amyloid fibrils. On the other hand, we showed that
in microglial cells of classical plaques in brain cortex
of patients with Alzheimer's disease, amyloid fibrils
appear first in altered endoplasmic reticulum and deep
infoldings of cell membranes. These differences in
intracellular distribution of amyloid fibrils in
microglial cells support our observations that
microglial cells associated with amyloid plaques are
engaged in production of amyloid, but not in
phagocytosis.
SO - Acta Neuropathol 1992 AUG;84(3):225-233
1
AU - Murdoch WW
AU - Nisbet RM
AU - Blythe SP
AU - Gurney WSC
AU - Reeve JD
TI - An involnerable age class and stabiity in delay-differential
parasitoid-host models
MH - NICHOLSON-BAILEY
MH - LOTKA-VOLTERRA
MH - APHYTIS MELINUS
SO - American Naturalist 1987; 129:263-282
DP - 1987
VI - 129
TA - AMERICAN NATURALIST
PG - 263-282
11
AU - Gurney WSC
AU - Nisbet RM
TI - Predator-prey fluctuations in patchy environments
MH - SPATIAL MODELS
MH - PATCHES
SO - Journal of Animal Ecology 197; 47:85-102
DP - 197
TA - JOURNAL OF ANIMAL ECOLOGY
PG - 85-102
VI - 47